Lets see...
I recently played fallout 3 for the first time and am in love with it so Fallout: New vegas in on my list for sure.
Dead rising 2, provided I see some gameplay footage first
Halo: Reach, of course
Force Unleashed 2, if its released this year
COD 7!!!
Splinter Cell: Conviction, I like where their taking the series so lets hope its a decent game
Rage, again if its released this year
Brink, looks interesting so I'll throw that on there as well